In St. Vincent, Maggie (Melissa McCarthy), a single mother, moves into a new home in Brooklyn with her 12-year-old son, Oliver (Jaeden Lieberher). Forced to work long hours, she has no choice but to leave Oliver in the care of their new neighbor, Vincent (Bill Murray), a retired curmudgeon with a penchant for alcohol and gambling. An odd friendship soon blossoms between the improbable pair. Together with a pregnant stripper named Daka (Naomi Watts), Vincent brings Oliver along on all the stops that make up his daily routine—the race track, a strip club, and the local dive bar. Vincent helps Oliver grow to become a man, while Oliver begins to see in Vincent something that no one else is able to: a misunderstood man with a good heart.
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